S1-hypersensitive sites in eukaryotic promoter regions
نویسندگان
چکیده
منابع مشابه
Stochastic segment models of eukaryotic promoter regions.
We present a new statistical approach for eukaryotic polymerase II promoter recognition. We apply stochastic segment models in which each state represents a functional part of the promoter. The segments are trained in an unsupervised way. We compare segment models with three and five states with our previous system which modeled the promoters as a whole, i.e. as a single state. Results on the c...
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Recent determination of human and mouse draft genome sequences should be the landmarks for the post-sequencing era. One of the major challenges in this era is the interpretation of the promoter regions. To this end, precise identification of the transcriptional start sites (TSSs) is essential. However, such an information cannot be obtained from usual cDNA or EST data. Although Eukaryotic Promo...
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Rat and human ribosomal RNA gene fragments in supercoiled plasmids were examined for S1 nuclease hypersensitivity. In the transcribed portion of genes the number and distribution of S1 sites were found to be species specific. No S1 sites were detected in the promoter regions. In the nontranscribed spacer (NTS), downstream of the 3' end of 28S RNA gene, S1 sites appear to be conserved in rat and...
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We present a new search-by-content method to identify transcriptional regulatory regions in eukaryotic genomic sequences. The method is based on stochastic language models which are a straightforward generalization of oligomer statistics. We describe the theoretical background and different parameter estimation techniques used to build the models. The resulting language models are applied to cl...
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By using a map of the unique region of DNA encoding the fur small heat-shock proteins of Drosophila melanogaster (hsp 22, hsp 23, hsp 26, and hsp 28), and a simple mapping technique, the positions of the DNase I hypersensitive sites of chromatin in the vicinity of these genes have now been determined. The major chromatin-specific sites occur at the 5' ends of each of the four heat-shock protein...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1984
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/12.21.8043